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UV Phototherapy vs. Biologics
| Raptiva™, Enbrel™ Amevive™ |
Versus |
Ultraviolet Light Phototherapy |
| Only 21% of patients achieve 75% PASI score (IM). On average only 29% of patients achieve 75% PASI score (IV). 1,2,3 |
Clearing at 12 Weeks |
Typically 20-25 treatments to clearing.
Long term remission for 90-95% of patients 4 |
| Suppress Immune System 5,A |
Side Effects |
Minimal Side Effects 6,7,B |
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Not Fully Reimbursed 8
Potentially high co-pays for patients. Single course of therapy every 6-12 months $12K-$18K. |
Cost |
Almost Always Reimbursed 8
Small co-pay for patient. |
| 12 IV, IM, or SC injection treatments per treatment cycle |
Simplicity of Use |
Standing in front of a light for 5-10 minutes |
| Too New for Safety Record 5 |
Safety |
Decades of Safe Use 9 |
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A. Side Effects of Biologics:
- Raptiva - "The most common side effects of Raptiva include headache, chills, fever, nausea and muscle aches. Back pain, joint pain and swelling of the arms and legs (peripheral edema) can also happen with Raptiva."
- Enbrel - "Many of these infections occured in patients predisposed to infections because of concomitant immunosuppresive therapy and/or their underlying disease. Rarecases of TB have been observed."
- Amevive - "Commonly observed adverse events seen in the first course were: pharyngitis, dizziness, increased cough, nausea, pruritus, myalagia, chills, injection site pain, injection site inflammation and accidental injury."
B. Side effects of Phototherapy
Narrowband lamping has been available in Europe since 1988 and with proper exposure has shown minimal side effects. |
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Bibliography
- Amevive. Advertisement. Journal of the American Academy of Dermatology. Jul. 2004: 858-859.
- Enbrel. Advertisement. Journal of the American Academy of Dermatology. Jul. 2004: 918-919.
- Raptiva. Advertisement. Journal of the American Academy of Dermatology. Jul. 2004: 938-939.
- Al-Suwaiden MD, Sami. "Clearence is not a realistic expectation of psoriasis treatment.." Journal of the American Academy of Dermatology. 0 Mar. 2000: 796-802.
- Windle, PharmD, Mary. eMedicine Health - Understanding Psoriasis Medications, Systemic Age. -1 2003. Emedicine Consumer Health. 9 Jul. 2004.
- Reviewed by Simon MD, Harvey. www.healthandage.com/html/well_connected/pdf/doc87. 10 Nov. 2003. Health and Age Centers. 9 Jul. 2004.
- Shelk J. and Morgan P.Narrow-band UVB: a practical approach. 12 Dec. 2000. Dermatol Nursing. 9 Jul. 2004.
- Herper, Matthew. J&J Edges Up On The Itch. 26 Mar. 2003. Forbes.com. 9 Jul. 2004.
- Price, MD, Norman. An Overview of Psoriasis Therapy. 1998. . 9 Jul. 2004.
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